| 摘要 |
This invention relates to novel, relatively low molecular weight, 36-38 amino acid polypeptides with a sequence of about 4,000 Da, essentially of the formula N-Ter-Ala-Asp-Cys-Val-Gly-Asp-Gly-Gln-X-Cys-Ala-Asp-Trp-Y-Gly-Pro-Tyr- Cys-Cys-Se r-Gly-Tyr-Tyr-Cys-Ser-Cys-Arg-Ser-Met-Pro-Tyr-Cys-Arg-Cys-Arg-Ser-Asp-Ser (Formula I) isolated and purified from the toxin of the spider Hololena curta, or synthetically produced, which are useful as insecticides and in the treatment of glutamate antagonist and calcium antagonist related pharmacological conditions. |
