SYNTHESIS OF ACYCLIC NUCLEOSIDE DERIVATIVES

摘要

A process for preparing a compound of the formula: wherein R10 is a C3-C21 saturated or monounsaturated, optionally substituted alkyl residue, the process comprising the steps of: a) reacting a compound of the formula: wherein R6 and R7 are lower alkyl or benzyl residues, or R6 and R7 taken together are -CH2CH2-, -CH2CH2CH2- or -CH2CH2CH2CH2- with R10COOH or an activated derivative thereof, wherein R10 is a C3-C21 saturated or monounsaturated, optionally substituted alkyl residue, to provide a compound of the formula: wherein R6, R7 and R10 are defined as above, b) de-protecting the acetal of the product of step a), and c) reducing the aldehyde substituent of the product of step b), characterized in that the products of steps a) and b) are not isolated.