发明名称 |
WERKWIJZE VOOR HET BEREIDEN VAN FARMACEUTISCHE, COSMETISCHE EN DIAGNOSTISCHE MATERIALEN. |
摘要 |
The process produces pharmaceutical, cosmetic or diagnostic formulations by the freeze drying of one or more substances in solution or in suspension in a solvent or a mixture of solvents. The solution or suspension is locally and progressively cooled in a controlled manner while agitating so as to produce microcrystals of solvent which are put in suspension in the remainder of the liquid until there is obtained a high-viscosity microcrystalline complex system comprising essentially isolated microcrystals of solvent in intimate mixture with interstitial liquid phases having a high concentration of the initially present substances. The microcrystalline complex system is hardened by cooling and lyophilized. This process permits the obtainment of lyophilized formulations having a higher dissolving or dispersing rate and lyophilized compositions of normally incompatible substances. |
申请公布号 |
NL186675(B) |
申请公布日期 |
1990.09.03 |
申请号 |
NL19780009522 |
申请日期 |
1978.09.19 |
申请人 |
SOCIETE ANONYME DITE: LABORATOIRE L. LAFON TE MAISONS-ALFORT, FRANKRIJK. |
发明人 |
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分类号 |
A61K49/00;A01N1/02;A61K8/00;A61K8/04;A61K8/11;A61K9/14;A61K9/19;A61K9/20;A61Q19/00;A61Q90/00;B01D9/04;B01D43/00;F26B5/06;F26B7/00;(IPC1-7):A61K9/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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