发明名称 |
Method for purification of antithrombin III using an anion exchanger |
摘要 |
A method of purifying antithrombin III (AT III) from a starting material containing an AT III/heparin complex or an AT III/heparinoid complex is disclosed. First, the method comprises adsorbing the AT III/heparin complex or the AT III/heparinoid complex on an anion exchanger material. Second, the method involves separating the AT III from the adsorbed AT III/heparin complex or an AT III/heparinoid complex by elution with a buffer having a pH ranging from 8.5 to 10.5 and a conductivity between 10 and 60 mS.
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申请公布号 |
US6395880(B1) |
申请公布日期 |
2002.05.28 |
申请号 |
US20000509052 |
申请日期 |
2000.05.26 |
申请人 |
BAXTER AKTIENGESELLSCHAFT |
发明人 |
LINNAU YENDRA;HETZL ERNST;MATTHIESSEN H. PETER;NEPPL SILVIA;SCHOENHOFER WOLFGANG;SCHWARZ HANS-PETER |
分类号 |
A61K38/00;C07K14/81;(IPC1-7):C12N9/74;A61K35/14;A23J11/00 |
主分类号 |
A61K38/00 |
代理机构 |
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