| 摘要 |
A polypeptide derived from leeches of the species Hirudinaria manillensis has the following amino-acid sequence: X-Y-tyr-thr-asp-cys-thr-glu-ser-gly-gln-asn-tyr-cys-leu-cys-val-gly-se r-asn-val- cys-gly-glu-gly-asp-asn-cys-asn-D- gln-leu-ser-ser-ser-gly-asn-gln-cys-val-E-gly-glu-gly-thr- pro-F-pro-gln-ser-gln-thr-glu-gly-asp-phe-glu-glu-ile-pro-asp-glu-Z-il e-lys; wherein X indicates any amino acid reisude; Y indicates any amino acid residue; Z indicates any amino acid residue; D indicates cys or pro; and E indicates glu or asp or his; F indicates asp, lys or trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament. |
