发明名称 |
PROCESS FOR PRODUCING SIALINIC ACID DERIVATIVES CONTAINING ACTIVE CARBONYL GROUP |
摘要 |
Sialic acid derivs., having an active carbonyl gp. of formula (I), amino-cpd. coupled sialic acid derivs. of formula (II), biological half-life extending agents for physiologically active materials comprising (I), and binder for affinity chromatography coupling gels comprising (I), are new, where R1 = H or Ac; R2 = H, a metal or lower alkyl; R2' = H, Na or lower alkyl; R3 = H, OH or active ester alcohol residue; X = residue of an amino cpd. having m reacted NH2 gps.; m = 1-60; and n = 1-20. Pref. X = residue of an amino acid, peptide or protein, or conjugated protein also contg. a prosthetic gp. |
申请公布号 |
HU902530(D0) |
申请公布日期 |
1990.08.28 |
申请号 |
HU19870006027 |
申请日期 |
1987.12.28 |
申请人 |
MECT CORP.,JP |
发明人 |
YOSHIMURA,SHOJI,JP;SHIBAYAMA,SHOHEI,JP;NUMATA,MASAAKI,JP;ITO,MASAYOSHI,JP;SHITORI,YOSHIYASU,JP;OGAWA,TOMOYA,JP |
分类号 |
A61K31/70;A61K31/7028;A61K47/26;A61P43/00;C07H15/04 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|