发明名称 |
NEW SULFATED POLYSACCHARIDE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION THEREOF, AND DRUG CONTAINING THE SAME AS ACTIVE INGREDIENT |
摘要 |
This invention relates to a sulfated polysaccharide D-HG, prepared by depolymerizing FGAG (an extract from the parietes of a sea cucumber comprising a sulfated polysaccharide having a heparinlike action) or its salt and having the following physicochemical properties, pharmaceutically acceptable salts thereof, a method for preparing the same, and drugs for treating diffuse intravascular coagulation (DIC) and thrombosis containing the same as the active ingredient: (1) molecular weight: 3000 to 42000 according to HP GPC; (2) form: white, amorphous and highly hygroscopic powder; (3) solubility: soluble in water and insoluble in organic solvents such as ethanol and acetone; (4) specific rotation: (a); (5) color reaction: Elson-Morgan reaction (+); carbozole-sulfuric acid reaction (+); cysteine-sulfuric acid reaction (+); orcinol-hydrochloric acid reaction (+); azure A metachromasia reaction (+); (6) compositional analysis: galactosamine : glucuronic acid : fucose : sulfate radical = 1 : 0.8 +/- 0.2 : 0.85 +/- 0.15 : 3.4 +/- 0.9. |
申请公布号 |
AU5032590(A) |
申请公布日期 |
1990.08.24 |
申请号 |
AU19900050325 |
申请日期 |
1990.02.06 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
HUI-ZENG FAN;ETSUJI YAMANAKA;YOSHIYUKI MURANAKA;SONG YU;KAZUHIRO NUMATA;TOSHINORI OKA;NORIHIKO SUZUKI |
分类号 |
A61K35/56;C07H1/08;C08B37/00 |
主分类号 |
A61K35/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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