发明名称 |
Psoralens aminomethylation |
摘要 |
A direct, acid-catalyzed substitution reaction incorporates an N-phthalimidomethyl group on the 4' or 5' carbon of a psoralen in yields of 60-80% via the condensation of an N-hydroxymethylamide or phthalimide (e.g. N-hydroxymethylphthalimide) and an appropriately substituted psoralen. The phthalimide moiety is cleaved from the psoralen ring by treatment with hydrazine to give 60 to 70% yields of the aminomethylpsoralens.
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申请公布号 |
US4950770(A) |
申请公布日期 |
1990.08.21 |
申请号 |
US19880220874 |
申请日期 |
1988.07.14 |
申请人 |
ELDER PHARMACEUTICALS, INC. |
发明人 |
HEINDEL, NED D.;CHOUDHURI, MRIDULA D. |
分类号 |
C07D493/04 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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