6-(SUBSTITUTED) METHYLENEPENICILLANIC AND 6- (SUBSTITUTED) HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF

摘要

6-(SUBSTITUTED)METHYLENEPENCILLANIC AND 6-(SUBSTITUTED)HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF Beta-lactamase inhibiting compounds of the formula or (I) (II) or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxyprotecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, arythio, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxamido or amidino groups; one of R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.