A NOVEL TETRACHLORORAFFINOSE AND ITS USE IN THE PREPARATION OF SUCRALOSE

摘要

The novel chlorinated sugar O- alpha -D-6-chloro-6-deoxygalactopyranosyl-(1->6)- alpha -D-4-chloro-4-deoxygalactopyranosyl-(1->2)- beta -D-1, 6-dichloro-1, 6-dideoxyfructofuranoside (TCR) can be used to prepare sucralose by incubating the TCR in solution in the presence of an enzyme serving to remove the 6-chloro-6-deoxygalactosyl moiety from the 6-position, especially an enzyme derived from a strain of Mortierella vinacea, Circinella muscae or Aspergillus niger. TCR is prepared by treating raffinose with thionyl chloride in the presence of triphenylphosphine oxide.