发明名称 |
METODOS PARA LA PREPARACION DE PEPTIDOS INSULINOTROPICOS, PARTICULARMENTE EL PEPTIDO SIMILAR A GLUCAGON 1 (GLP-1) Y LOS HOMOLOGOS DEL MISMO, UTILIZANDO PROCESOS EN FASE SOLIDA Y EN SOLUCION; FRAGMENTO PEPTIDICO UTIL EN LA PREPARACION DEL PEPTIDO INSU |
摘要 |
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase ("hybrid") approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts. |
申请公布号 |
CL2007001835(A1) |
申请公布日期 |
2008.03.14 |
申请号 |
CL20070001835 |
申请日期 |
2007.06.22 |
申请人 |
F. HOFFMANN-LA ROCHE AG. |
发明人 |
LIN CHEN, YEUN-KWEI HAN, CHRISTOPHER R.ROBERTS |
分类号 |
C07K1/02;C07K1/04;C07K14/605 |
主分类号 |
C07K1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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