Process for obtaining ciprofloxacin

摘要

Process for obtaining ciprofloxacin, having the chemical name 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl) quinoline-3-carboxylic acid of formula I, its addition salts with pharmaceutically acceptable acids and its hydrates based on the reaction of n-cyclopropyl-3- chloro-4-fluoroaniline with diethylethoxy methylene malonate and then performing an in situ cyclisation reaction which provides a quinolone compound of formula V, the condensation of which with an excess of n-ethoxy carbonyl piperazine yields an intermediate of formula VI which by hydrolysis and neutralisation yields the compound of formula I. Ciprofloxacin is a bactericidal or immunostimulating agent having a wide spectrum for the treatment of diseases caused by Gram-positive and Gram-negative bacteria. <IMAGE>