| 摘要 |
<p>Disclosed are novel carbapenem derivatives characterized by a non-hydrogen substituent in the 1position of the carbapenem ring and a 2-substituent of the formula in which A represents cyclopentylene, cyclohexylene or C2 C6 alkylene optionally substituted by one or more C1-C4 alkyl groups; R5 represents either (a) an optionally substituted aliphatic, cycloaliphatic, cycloaliphaticaliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical or (b) a divalent phenylene or C1-C4 alkylene group joined to the ring so as to form a bridged polycyclic group; and represents a quaternized nitrogen-containing non-aromatic heterocycle. Such derivatives are useful as potent antibacterial agents.</p> |
