发明名称 |
Immobilized antibodies |
摘要 |
Antibodies which are immobilized and covalently bound to a matrix polymer by means of a modification in a carbohydrate region of the antibodies; wherein the binding of the antibodies is effected by condensing at least one aldehyde group in an oxidized carbohydrate region and at least one epoxide function of an epoxy-group-containing matrix polymer, said condensation being conducted in the presence of a bifunctional reagent which has, on one end position of a spacer unit having at least three members, an amino group capable of condensing with the aldehyde group, and which has on the other end position a group which reacts covalently with the epoxide function.
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申请公布号 |
US4948836(A) |
申请公布日期 |
1990.08.14 |
申请号 |
US19880270280 |
申请日期 |
1988.11.14 |
申请人 |
ROEHM GMBH CHEMISCHE FABRIK |
发明人 |
SOLOMON, BEKA;HADAS, ERAN;FLEMINGER, GIDEON |
分类号 |
A61K39/44;C07K16/00;C07K17/06;C07K17/08;C12P21/08;G01N33/543;G01N33/545;G01N33/547;G01N33/548 |
主分类号 |
A61K39/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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