POLYUNSATURATED FATTY ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, METHOD FOR THE PREPARATION THEREOF, AND THEIR USE AS MEDICAMENT

摘要

PCT No. PCT/HU90/00004 Sec. 371 Date Sep. 12, 1990 Sec. 102(e) Date Sep. 12, 1990 PCT Filed Jan. 16, 1990 PCT Pub. No. WO90/08130 PCT Pub. Date Jul. 26, 1990.The compounds of the Formula (I) (I) wherein R1 is a C18-24alkenyl containing at least two double bonds, or -(CH2)n -CH(NH2)m -COOH X is 0, NH or C1-4alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is hydrogen metal, and R2 is a side chain of a any amino acid except L-GLU or L-ASP at alpha -position or a group of Formula -(CH2)k-C6H3-(A)2(II), -(CH2)n-X-(CH2)m-X-M(III) wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, A is hydroxyl or one A is hydroxyl and the other A is hydrogen. M is H or R1-CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.