| 摘要 |
A C-terminal alpha -amidating enzyme of human thyroid gland origin, which converts a protein or peptide represented by the formula R-X-Gly, wherein Gly represents glycine present at the C-terminus, X represents any amino acid to be alpha -amidated, and R represents a remaining portion of the protein or peptide, to an alpha -amidated protein or peptide represented by the formula R-X-NH2, wherein X-NH2 represent C-terminal alpha -amidated amino acid, and R represents a remaining portion of the protein or peptide, and biologically active derivative maintaining the enzyme activity thereof, a process for the production thereof, and expression vectors, and a prokaryotic and eukaryotic transformant for the process. |
