| 摘要 |
There are provided azino rifamycin compounds of the formula (I): <IMAGE> (I) Y=H or CH3CO; R1 linear or branched C1-C7 alkyl or C3-C4 alkenyl- R2=linear or branched C1-C7 alkyl, C2-C4 chloroalkyl, C3-C4 alkenyl, Cycloalkyl having 3 to 7 C atoms in the ring, cycloalkyl alkyl having 3 to 6 C atoms in the ring, phenyl, or C7-C8 aralkyl, unsubstituted or mono-substituted by a halogen atom in the aryl group; or NR1R2=a cyclic moiety having 5 to 8 C atoms, unsubstituted or substituted by 1 or 2 CH3 groups, morpholino. The compounds inhibit the growth of gram positive bacteria and Mycobacterium tuberculosis. Oxidized compounds, preparative methods and pharmaceutical compositions are also described and claimed. |
