| 摘要 |
<p>The present invention is directed to a stabilized cross-linked hydrogel matr ix comprising a first high molecular weight component and a second high molecul ar weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffol ds for implantable medical devices, and casting or binding materials suitable f or the construction of medical devices. The intrinsic bioactivity of the hydrog el matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implante d device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissu e bulking.</p> |
