VIPER VENOM POLYPEPTIDES AND VARIANTS

摘要

7273P/ 2/7/89:Fl 17749IB TITLE OF THE INVENTION VIPER VENOM POLYPEPTIDES AND VARIANTS A platelet aggregation inhibiting polypeptide having the following amino acid seguence: wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid. Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation, They are useful in inhibition of platelet aggregation formation.