Novel piperazinylalkyl-3(2H)-pyridazinones, process for their preparation and their use as hypotensive agents

摘要

The invention relates to novel piperazinylalkyl-3(2H)-pyridazinones of the formula <IMAGE> in which R1 is hydrogen, phenyl, benzyl, or (C1-C6)-alkyl which is unsubstituted or mono- or polysubstituted by hydroxyl, piperidine, morpholine or by a group NR4R5 in which R4 and R5 can be identical or different and are hydrogen, methyl or ethyl, R2 and R3 are hydrogen, halogen, (C1-C6)-alkoxy or (C1-C6)-alkyl, where at least one of the radicals R2 or R3 is hydrogen, R6 is hydrogen, (C1-C4)-alkyl, phenyl, benzyl or phenylethyl, B is (C1-C7)-alkylene which is unsubstituted or mono- or polysubstituted by hydroxyl, (C1-C4)-alkyl or by the group NR4R5 and can optionally be closed to give an alicyclic 4- to 7-membered ring, R8 and R9, which can be identical or different, are hydrogen or (C1-C6)-alkyl and Z is phenyl, naphthyl, pyridyl or thiazolyl, unsubstituted or mono- or polysubstituted by (C1-C6)-alkyl, (C1-C6)-alkoxy, benzyloxy, trifluoromethyl, halogen, nitro, (C3-C7)-cycloalkoxy, (C1-C4)-alkylthio, trifluoromethylthio or by the group NR4R5, their pharmaceutically utilisable salts, a process for their preparation and their use as a medicament for the treatment of hypertension, cardiac insufficiency and peripheral circulatory disorders.