| 摘要 |
PURPOSE:To prepare the titled substance, by cultivating a yeast, belonging to the genus Saccharomyces, Candida or Hansenula, and having the ability to produce the titled substance, in a culture medium containing a lower peptide constituted of glycine and/or alanine. CONSTITUTION:A yeast, e.g. Saccharomyces cerevisiae IFO 2346, belonging to the genus Saccharomyces, Candida or Hansenula, and having the ability to produce S-adenosyl methionine is cultivated in a culture medium containing the methionine, glycine, alanine or a lower peptide constituted of the glycine and alanine. The lower peptide is added to the culture medium according to the conventional method in a concentration of 0.02g/dl or more, and the cultivation is carried out under aerobic conditions at 3-8 pH for 2-10 days. The resultant S- adenosyl methionine is then collected from the microbial cell and/or culture fluid. |
