发明名称 |
PROTEINACEOUS ANTIGENS WITH CONFORMATION-INDEPENDENT AND CONFORMATION-DEPENDENT DETERMINANTS |
摘要 |
<p>A single polypeptide antigen that includes the amino acid residue sequence and epitope of a conformation-independent antigenic determinant and the amino acid residue sequence but lacks the epitope of a conformation-dependent antigenic determinant is disclosed as are methods of its manufacture and use and articles of manufacture using the same. The uses of the pre-S(2) region polypeptide encoded by the hepatitis B virus genome as a T cell proliferating agent and as a potentiator for enhancing the humoral immune response of animals that exhibit a low humoral response to an S region-containing immunogen are also disclosed.</p> |
申请公布号 |
CA1272126(A) |
申请公布日期 |
1990.07.31 |
申请号 |
CA19860503396 |
申请日期 |
1986.03.05 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
MILICH, DAVID J.;CHISARI, FRANK |
分类号 |
G01N33/531;A61K39/00;A61K39/29;C07K1/00;C07K14/02;C07K16/00;C12N15/00;C12N15/02;C12P21/00;C12R1/91;G01N33/576;(IPC1-7):C07K3/00;C07K17/00 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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