A SYSTEM FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS AND A PROCESS FOR ITS PREPARATION

摘要

22 A System for the Controlled Release of Active Agents and a Process for its Preparation The invention relates to a system for the controlled release of active agents and a process for its preparation, preferably an orally administrable pharmaceutical preparation for various, especially soluble, pharmaceutical agents, having even, controlled active agent release essentially caused by convective processes. The system of the invention is similar in therapeutic effectivity to an intravenous drip, i.e. the even and complete release of the active agent from the pharmaceutical preparation for a physiologically and therapeutically practical period of time caused by essentially convective processes. This leads to a constant therapeutic blood level which guarantees the long-term effect of the drug whilst reducing the adverse effects and improving local tolerance in the gastrointestinal tract at the same time. Furthermore, with the composition according to the invention of the pharmaceutical preparation and the preparation process according to the invention, damages to the shell controlling the release of the pharmaceutical agent will not lead to dose-dumping, as is usually the case in membranecontrolled pharmaceutical agent release, and the preset release rate will be reached within a short period of time.