PROCESS FOR PRODUCTION OF NEUTROPHIL-ACTIVIZATING FACTOR
摘要
Neutrophil-activating factor (NAF) is claimed. More specifically it has the qiven complete amino acid sequence. Also claimed is DNA having the nucleotide sequence indicated and equivalents suitable for expression in E.coli of NAF. - The total amino acid sequence of NAF purified from LPS-stimulated human monocytes has been detd. and a gene coding for the main NAF species synthesised and expressed as a recombinant peptide with the same neutrophil-activating properties as its natural homologue.
申请公布号
HUT52551(A)
申请公布日期
1990.07.28
申请号
HU19880006790
申请日期
1988.11.12
申请人
SANDOZ AG.,CH;THEODOR KOCHER INSTITUT,CH
发明人
ASCHAUER,HEINRICH,AT;LINDLEY,IVAN JAMES DALDON,AT;PEVERI,PAOLA,CH;WALZ,ALFRED,CH