| 摘要 |
<p>The compounds of formula (I), wherein R1 is a C18-24 alkenyl containing at least two double bonds, X is O, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is metal, and R2 is a side chain of a natural amino acid at α-position or a group of formulae (II): -(CH2)k - C6H3 - (OH)2, (III): -(CH2)n - X - (CH2)m - X - Me or (IV): -(CH2)n - CH(NH2) - COOH, wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, M is H or R1-CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.</p> |
