New silica-based thiophilic adsorbents are obtained by silanizing silica, cleaving the resulting epoxy groups and reacting the product with divinylsulfone, followed by treatment with mercaptoethanol. Adsorbents have utility in HPL chromatography and in purification of proteins e.g. monoclonal antibodies and immunoglobulins.
申请公布号
DE4002044(A1)
申请公布日期
1990.07.26
申请号
DE19904002044
申请日期
1990.01.24
申请人
YEDA RESEARCH AND DEVELOPMENT CO., LTD., REHOVOT, IL
发明人
WILCHEK, MEIR, REHOVOT, IL;NOPPER, BERNARD, 7300 ESSLINGEN, DE;KOHEN, FORTUNE, TEL AVIV, IL