摘要 |
A potentially large group of endogenous peptides is involved in mediating MHC-restricted T-cell recognition of antigens, and that recognition can be modulated by means of peptides that replace such endogenous peptides at the binding site on the class II molecule which interacts with the T-cell receptor. The replacing peptides can thus be used to regulate mammalian immune responses by influencing the recognition of an alloantigen or an autoantigen by T cells, for example, in the context of treating an immune disorder, overcoming allograft rejection or affecting an allergenic response. |