发明名称 |
NOVEL QUINOLYLOXAZOLE-2-ONES USEFUL AS PROTEINKINASE C INHIBITORS |
摘要 |
This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide. |
申请公布号 |
ZA8907259(B) |
申请公布日期 |
1990.07.25 |
申请号 |
ZA19890007259 |
申请日期 |
1989.09.22 |
申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
WINTON DENNIS JONES;RICHARD CYRUS DAGE;GEORGE PHILIP CLAXTON;HSIEN CHANG CHENG;PHILLIP JAMES ROBINSON |
分类号 |
A61K31/47;A61P9/08;A61P9/12;A61P11/08;A61P43/00;C07D215/14;C07D413/04 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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