发明名称 |
PRODUCTION METHOD OF (R.S)-3-(3-TERBUTYLAMINO-2-HIDROXYPROPOXY)-4-(N-MORPHOLINE)-1,2,5-THIIADIAZOLE |
摘要 |
(R,S)-3-(3-tertbutyl -amino-2-hydroxypropoxy) -4-(N-morpholino) 1,2,5-thiadiazole, (R,S)timolol base) is prepd. by amino-alkylation of 3-(2,3 epoxy-propxy) -4-(N-morpholino)-1,2,5 -thiadiazole, in an excess of tert-butylamine at reflux for a set time. 90-95% yield and 95-98% purity is achieve
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申请公布号 |
RO100032(A2) |
申请公布日期 |
1990.07.19 |
申请号 |
RO19880135258 |
申请日期 |
1988.09.26 |
申请人 |
INSTITUTUL DE CERCETARI CHIMICO-FARMACEUTICE, BUCURESTI, RO |
发明人 |
ILIE CORINA,RO;PUTINA GABRIELA,RO;CILIANU STELIANA,RO;BURGHELEA TEODOR,RO;IONESCU M. SIMINA,RO;COSOFRET VASILE,RO;BELTU CONSTANTINA,RO |
分类号 |
C07D285/10;(IPC1-7):C07D285/10 |
主分类号 |
C07D285/10 |
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