VERFAHREN ZUR HERSTELLUNG VON MIKROKAPSELN, WELCHE EINE SCHNELLE ABGABE DES WIRKSTOFFES AUS IHNEN BEZIEHUNGSWEISE DEN AUS IHNEN HERSTELLBAREN TABLETTEN UND DIE UNMITTELBARE TABLETTIERUNG VON ARZNEIMITTELWIRKSTOFFEN GEWAEHRLEISTEN

摘要

The invention relates to the preparation of microcapsules ensuring direct tablet compression of a drug and rapid release of the drug as active ingredient from the tablets, which comprises microencapsulating the crystal granules of cyclohexane-insoluble active ingredients with a particle size of at most 1000 mu m, preferably smaller than 60 mu m and particularly preferably smaller than 30 mu m, in cyclohexane medium with ethylcellulose taken in an amount of 1:30 to 1:5, preferably 1:20 to 1:10, in relation to the core material, if desired, in the presence of 0.001 to 1.0% by weight/volume, preferably 0.01 to 0.05% by weight/volume, of an anionic surface-active agent; or post-treating the drug granules microencapsulated with ethylcellulose by a cyclohexane-dissolved surface-active agent taken in an amount of 0.001 to 1.0% by weight/volume, preferably 0.1 to 0.5% by weight/volume, in relation to cyclohexane.