发明名称 |
RENSING AV N-L-ALFA- ASPARTYL-L-FENYL-ALANIN-1-METYL-ESTER |
摘要 |
A process for the preparation of the N-L- alpha -aspartyl-L-phenylalanine 1-methyl ester (aspartame) which is characterized by adding phosphoric acid and a lower alkyl alcohol to the reaction mixture containing N-formyl alpha -L-aspartyl- and beta -L-aspartyl-L-phenyl-alanine methyl ester and only one of the resultant deformylated isomers, i.e. aspartame phosphate precipitates. The alpha -isomer phosphate is collected by filtration and converted to free aspartame by treatment with a base. |
申请公布号 |
NO163738(C) |
申请公布日期 |
1990.07.11 |
申请号 |
NO19840002129 |
申请日期 |
1984.05.29 |
申请人 |
FARMITALIA CARLO ERBA SPA |
发明人 |
OPPICI, ERNESTO;DALLATOMASINA, FRANCO;GIARDINO, PIETRO |
分类号 |
C07C231/00;A23L27/30;C07K5/072;C07K5/075 |
主分类号 |
C07C231/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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