摘要 |
PURPOSE:To inexpensively obtain the subject compound useful as an intermediate for methylcarbapenem which is a stable antimicrobial agent by using an oxo-dioxan derivative as a starting raw material and treating with a halopropionic acid derivative in the presence of zinc powder. CONSTITUTION:A 2-oxo-1,3-dioxan derivative expressed by formula I is treated with an alpha-halopropionic acid derivative expressed by formula II (X represents Cl, Br, etc.; R<1> to R<4> represent H, aryl, etc.) in the presence of zinc powder to afford the objective compound expressed by formula III (R<5> represents H or OH-protecting group). Normally 1-3 equivalents compound expressed by formula II and 2-5 equivalents zinc powder are preferably used based on 1 equivalent compound expressed by formula I. The reaction is preferably carried out in THF, etc., at 0-100 deg.C. The starting raw material compound expressed by formula I is preferably prepared by normally using a (R)-3-hydroxybutyric acid as the starting raw material. |