发明名称 Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds
摘要 This invention provides novel tetrazole intermediates of the formula <IMAGE> wherein R1 and R4 each are independently hydrogen, halogen, C1-4alkyl, C1-4alkoxy or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen, C1-4alkyl or C1-4alkoxy; B is hydrogen, C1-4alkoxycarbonyl, CH2Y or CH2Z; Y is hydrogen, hydroxyl or X; Z is <IMAGE> X is bromo, chloro or iodo; R10 is C1-4alkyl; and R11 is phenyl which is unsubstituted or substituted by one or two C1-4alkyl or chloro substituents. and processes thereof which are useful for the preparation of antihypercholesterolemic agents.
申请公布号 US4939265(A) 申请公布日期 1990.07.03
申请号 US19890430029 申请日期 1989.11.01
申请人 BRISTOL-MYERS COMPANY 发明人 WRIGHT, JOHN J.;SIT, SING-YUEN;BALASUBRAMANIAN, NEELAKANTAN;BROWN, PETER J.
分类号 C07D257/04;C07D405/06;C07F9/6524 主分类号 C07D257/04
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