| 摘要 |
PURPOSE: To obtain the subject agent for oral administration, composed of a lipid matrix which is solid at body temperature and a drug embedded in the matrix, having the shape of fine particles with a specific maximum diameter, effective for protecting the gastrointestinal tracts from topical stimulation and having improved bioavailability of the drug. CONSTITUTION: A lipid substance taking solid state at body temperature and capable of forming a non-toxic biologically compatible water-insoluble carrier fluid (e.g. sterol, triglyceride, especially partially hydrogenated long-chain triglyceride and/or hydrogenated long-chain triglyceride) is melted and a biologically active agent is added to the melted carrier fluid to obtain a lipid-drug dispersion. The liquid dispersion is solidified to obtain fine particles of lipid-drug composed of the drug embedded in the lipid matrix and having a maximum diameter of about 500μm. The releasing agent is especially suitable for the peroral release of ferrous sulfate as an agent for the treatment and/or prevention of iron deficiency of adult.
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