PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF TETRAZOLE DERIVATIVES DECREASING PATHOLOGICALLY HIGH CHOLESTANOL LEVEL OF THE BLOOD

摘要

Compounds of the formula I wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoromethyl; R2, R3, R5 and R6 each are independently hydrogen, halogen C1-4 alkyl or C1-4 alkoxy; tet is n is an integer of from 0 to 2, inclusive; A is R7 is hydrogen, C1-4 alkyl, C1-4 alkoxy(lower) alkyl or (2-methoxyethoxy)methyl; X is -OH or =O; and R8 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.