发明名称 |
New retro-inverso analogues of trymopentin, the method for their synthesis and their use in the preparation of pharmaceutical compositions. |
摘要 |
<p>New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5<1><-><4>) containing two non-contiguous retro-inverted bonds in the peptide chain are described. The new compounds, of general formula (I) <CHEM> where R is hydrogen or an acyl radical, and R<1> is an -OR<2> group or an <CHEM> group where R<2> is a hydrogen atom or a hydrocarbon radical, and R<3> is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.</p> |
申请公布号 |
EP0375058(A2) |
申请公布日期 |
1990.06.27 |
申请号 |
EP19890203230 |
申请日期 |
1989.12.18 |
申请人 |
SCLAVO S.P.A. |
发明人 |
MARIOTTI, SABINA;SISTO, ALESSANDRO;NENCIONI, LUCIANO;VILLA, LUIGI;VERDINI, ANTONIO SILVIO |
分类号 |
A61K31/195;A61K31/215;A61K31/22;A61K38/00;A61P37/00;A61P43/00;C07C279/12;C07K5/02;C07K7/02 |
主分类号 |
A61K31/195 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|