SEMICARBAZIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

Semicarbazide derivatives of the formula: wherein R1 is hydrogen, R2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, R3 is lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, or R2 and R3 are taken together to form (C2-C6)- alkylidene group optionally substituted with aryl or taken together with the adjacent nitrogen atom to form a saturated or unsaturated, 5- or 6-membered heterocyclic group optionally substituted with aryl; or R1 and R2 are taken together with the adjacent nitrogen atoms to form a saturated or unsaturated, 5- or 6-membered heterocyclic group or 1,2-diazaspiroalkane-1,2-diyl group, R3 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl; R4 is aryl which may have substituent(s) selected from lower alkyl, halogen lower alkoxy, lower alkylamino, halo(lower)alkyl, hydroxy, lower alkanoyl, esterified carboxy and carboxy, R5 is hydrogen or lower alkyl, and X is O or S, provided that the lower alkyl group for R3 is (C3 -C6) alkyl, when R2 is hydrogen or (C1-C2) alkyl and R4 is aryl optionally having substituent(s) selected from groups consisting of halogen, lower alkyl, lower alkoxy and halo(lower)alkhyl, and their pharmaceutically acceptable salts may be used as anti-inflammatory and analgesic agents.