| 摘要 |
entitled: Method of preparing chroman derivatives, and synthesis intermediates in the names of: Georges GARCIA Daniel METTEFEU Richard ROUX Assignee: SANOFI The invention describes a method of synthesizing a compound of the formula (I) in which - X = O or NR, - Z = an electron-attracting group, - R = H, CN or NO2, - R1 + Rz + N-C=X = a 5-membered or 6-membered hetero cycle, and - R3 = H, R4 = OH or R3 + R4 = a bond, said method involving intermediates of the formula (IX) in which R5 = H, Br or N(R1)CXR2. This method of synthesis does not involve the epoxide derivative of the chroman. The novel compounds of formula (IX) form a further subject of the invention.
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