发明名称 |
METHOD FOR PREPARING A-(4-ISOBUTYLPHENYL) PROPIONIC ACID OR ITS PRECURSOR |
摘要 |
A method for preparing .alpha.-(4-isobutylphenyl) propionic acid or its precursor is here disclosed which comprises a step (I) of dehydrogenating p-isobutylethyl-benzene in a gaseous phase in the presence of a dehydrogenating metal catalyst to form p-isobutylstyrene and at least one unsaturated hydrocarbon compound selected from the group consisting of 4-(2'-methyl-1'- propenyl)ethylbenzene, 4-(2'-methyl-1'-propenyl) vinylbenzene, 4-(2'-methyl-2'-propenyl)ethylbenzene, and 4-(2'-methyl-2'-propenyl)vinylbenzene; a step (II) of reacting p-isobutyl-styrene obtained in the step (I) with carbon monoxide and hydrogen or with carbon monoxide and water or a lower alcohol in the presence of a transition metal complex carbonylating catalyst to form .alpha.-(4-isobutylphenyl)propionic acid or its precursor; and a step (III) of hydrogenating at least one unsaturated hydrocarbon compound selected from the group A obtained in the dehydrogenation step (I) to form p-isobutylethylbenzene, and recycling the thus formed p-isobutylethylbenzene through the step (I) as the raw material of the step (I). The .alpha.-(4-isobutylphenyl) propionic acid so prepared is useful as a medicine (an analgesic).
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申请公布号 |
CA2005845(A1) |
申请公布日期 |
1990.06.21 |
申请号 |
CA19892005845 |
申请日期 |
1989.12.18 |
申请人 |
NIPPON PETROCHEMICALS CO., LTD. |
发明人 |
SHIMIZU, ISOO;MATSUMURA, YASUO;TOKUMOTO, YUICHI;KAZUMICHI, UCHIDA |
分类号 |
C07C5/333;C07C45/50;C07C45/62;C07C51/14;C07C51/255 |
主分类号 |
C07C5/333 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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