| 摘要 |
PURPOSE:To obtain a liposome preparation having excellent stability by treating a flavonoid with an alkaline solution and converting into liposome. CONSTITUTION:A phospholipid or a mixture of phospholipid and cholesterol is formed in the form of a thin film by reverse-phase evaporation process. A solution of free flavonoid dissolved in an alkaline solution having pH of >=10 is added to the thin film and uniformized by ultrasonic process to obtain a stable emulsion. The objective liposome preparation containing a flavonoid is produced by treating the emulsion with an extruder. The preparation can be infused into a body by intravenous or transperitoneal infusion to keep high flavonoid concentration in the body and is effective as a platelet coagulation inhibitor, a vasodilator, an antihistaminic, an anti-inflammatory, an antispasmodic, an estrone-like agent and a scavenger for free radical, etc. |
