| 摘要 |
PURPOSE:To obtain a hair tonic, containing a specific pyrimidine N-oxide derivative and having excellent alopecic preventive and trichogenous effects. CONSTITUTION:A hair tonic containing 0.001-15wt.%, preferably 0.1-10wt.% compound expressed by formulas I and II (R1 is 1-8C alkyl; R is H, 1-8C alkyl, Br, Cl, NO2 or NH2; R3 and R4 are H, 1-8C alkyl, 3-8C alkenyl, phenyl-1-6C alkyl or 3-8C cycloalkyl or, together with N, may form aziridinyl, pyrrolidinyl, piperidino, etc., provided that both are not simultaneously H) or a compound expressed by formula III (X is F, Cl or Br; n is 0-3; R is Cl, Br, I, NO2, NO, NH2, H 1-8C alkyl, 3-8C alkenyl, phenyl, etc.), acylated substance, tautomer or acid addition salt thereof, e.g. 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide. |
