| 摘要 |
PURPOSE:To prepare the titled compound in high yield, preventing the lowering of the catalytic activity and the selectivity of methanol with time, by contacting a phenolic compound with methanol in vapor phase in the presence of a specific metal oxide catalyst, thereby selectively methylating the o-position of the phenolic compound. CONSTITUTION:The objective compound can be prepared by containing (A) the phenolic compond of formula II (R1, R2, R3 and R4 are H or saturated aliphatic hydrocarbon group such as methyl, ethyl, isopropyl, tertiary butyl, etc.) with (B) methanol in vapor phase, in the presence of (C) a metal oxide of formula I [A is one or more elements selected from alkali metals; the subscripts a, b and c are atomic ratios based on vanadium element 1, and a=0.1-10, 0<b/ (1+a)<0.5, c=0-0.2] at 280-400 deg.C, thereby selectively methylating the o-position of the phenolic compound. The ratio of methanol to the compound of formula II is preferably 1:2-8. |
