发明名称 |
Imidazolyl and pyridyl derivatives of phenyl substituted 1,4 -dihyropyridines and process for their preparation. |
摘要 |
<p>Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) <CHEM> A represents a direct linkage, -CH2-, CH2-CH2- or, when Het is <CHEM> A may also represent -CH=CH-; R is hydrogen, halogen, C1-C3 alkyl or C1-C3 alkoxy; each of R3 and R4 is a C1-C3 alkyl group; one of R1 and R2 is a group -OR min wherein R min is a C1-C6 alkyl ether unsubstituted or omega substituted by C1-C3 alkoxy or cyano, and the other is, independently, a) a group -OR min ; b) a group <CHEM> or c) a group -OR<IV> wherein R<IV> is hydrogen or a substituent selected from: <CHEM> are useful as Thromboxane A2 (TxA2 ) Synthase inhibitors and as calcium antagonists.</p> |
申请公布号 |
EP0373645(A1) |
申请公布日期 |
1990.06.20 |
申请号 |
EP19890123111 |
申请日期 |
1989.12.14 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
COZZI, PAOLO;CARGANICO, GERMANO;MENICHINCHERI, MARIA;SALVATI, PATRICIA |
分类号 |
A61K31/445;C07D213/50;A61K31/44;A61K31/4427;A61K31/495;A61P7/02;C07D401/10;C07D401/14;C07D521/00 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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