Comosition for controlled release of polypeptides.

摘要

Stable somatotropin compositions are provided that are suitable for long term administration of somatotropin by infusion devices. The composition contains at least about 10% bioactive somatotropin, an effective amount of a stabilizing polyol and a buffer to achieve a pH at which bioactivity is retained over time, such as a pH range from about 4.5 to either about 7 or the isoelectric point of the somatotropin, whichever is greater.