发明名称 |
Anti-thrombins. |
摘要 |
<p>A polypeptide derived from leeches of the species Hirudinaria manillensis has the following amino-acid sequence: X-Y-tyr-thr-asp-cys-thr-glu-ser-gly-gln-asn-tyr-cys-leu-cys-val-gly-se r-asn-val- cys-gly-glu-gly-asp-asn-cys-asn-D- gln-leu-ser-ser-ser-gly-asn-gln-cys-val-E-gly-glu-gly-thr- pro-F-pro-gln-ser-gln-thr-glu-gly-asp-phe-glu-glu-ile-pro-asp-glu-Z-il e-lys; wherein X indicates any amino acid reisude; Y indicates any amino acid residue; Z indicates any amino acid residue; D indicates cys or pro; and E indicates glu or asp or his; F indicates asp, lys or trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament.</p> |
申请公布号 |
EP0373767(A1) |
申请公布日期 |
1990.06.20 |
申请号 |
EP19890311739 |
申请日期 |
1989.11.13 |
申请人 |
BIOPHARM (UK) LIMITED |
发明人 |
SAWYER, ROY;POWELL-JONES, CHRISTOPHER;ATKINSON, ANTHONY;ELECTRICWALA, ASGAR |
分类号 |
A61K38/46;A61K35/62;A61K38/00;A61K38/04;A61K38/08;A61K38/55;A61P7/02;C07K7/08;C07K14/81;C07K14/815 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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