| 发明名称 |
Cyclosporin derivatives with modified 8-amino acid. |
| 摘要 |
<p>A new cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.</p> |
| 申请公布号 |
EP0373260(A1) |
申请公布日期 |
1990.06.20 |
| 申请号 |
EP19880202845 |
申请日期 |
1988.12.12 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
PATCHETT, ARTHUR A.;WHITE, RAYMOND F.;GOEGELMAN, ROBERT T. |
| 分类号 |
A61K38/00;C07K7/64;C12P21/04;C12P21/08;(IPC1-7):C07K7/64;A61K37/02 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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