1.4-dihydropyridines

摘要

Compounds are described of the formula <IMAGE> (I) wherein R1 represents a formyl or nitrile group or a group OCH2A where A represents hydroxy, C1-4 alkoxy or D(CH2)nNR7R8 (where R7 and R8 independently represent hydrogen or C1-4 alkyl and n is 2 or 3); R2 and R3 independently represent a C1-6 straight or branched alkyl chain or alkoxy group; R4 represents a C1-4 alkyl group; R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by a C1-3 alkyl substituent; R6 represents a halogen atom or a straight or branched C1-3 alkyl group. The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.