| 摘要 |
<p>Human monoclonal immunoglobulin and immunoglobulin fragments that are specific for blood platelets are described. The immunoglobulin, or fragment thereof, are, preferably, specific for the glycoprotein IIb/IIIa receptor in its complexed form. These antibodies block ligand binding to the receptor, thereby preventing platelet aggregation which has been implicated in the formation of thrombi. These immunoglobulines are useful in anti-thrombotic therapy alone or in conjunction with thrombolytic agents, and in scintigraphic imaging of thrombi.</p> |
