发明名称 Use of heterocyclic amides to inhibit tumor metastasis.
摘要 <p>A method of inhibiting tumor metastasis in an animal by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: &lt;CHEM&gt; wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a &lt;CHEM&gt; group wherein q, r and t are independently an integer of from 1 to 8 provided that q + r + t is equal to or less than 10; Y is thio or sulfinyl; Alk is straight or branched chain lower alkylene, and R3 is a heterocyclic amine represented by the formula: &lt;CHEM&gt; wherein R4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, or substituted benzyl; p is 0 to 2; or a pharmaceutically acceptable salt thereof.</p>
申请公布号 EP0372410(A2) 申请公布日期 1990.06.13
申请号 EP19890122192 申请日期 1989.12.01
申请人 G.D. SEARLE & CO. 发明人 FULLER, GEORGE CHARLES;MARTIN, GEORGE REILLY;MUELLER, RICHARD AUGUST;REICH, REUVEN
分类号 C07D295/18;A61K31/495;A61P43/00;C07D241/04 主分类号 C07D295/18
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