COMPOSITION FOR CONTROLLED RELEASE OF POLYPEPTIDES

摘要

37-21 (10208)A COMPOSITION FOR CONTROLLED RELEASE OF POLYPEPTIDES Stable somatotropin compositions are provided that are suitable for long term administration of somatotropin by infusion devices. The composition contains at least about 10% bioactive somatotropin, an effective amount of a stabilizing polyol and a buffer to achieve a pH at which bioactivity is retained over time, such as a pH range from about 4.5 to either about 7 or the isoelectric point of the somatotropin, whichever is greater.